GENOME-WIDE FOOTPRINTING OF TRANSCRIPTION FACTORS (TF) WITH DEAMINASE (FOODIE) AND PREDICTION OF ANY TF’S BINDING AFFINITY ON DNA
FOODIE is a transformative approach for genome-wide footprinting of transcription factors with deaminaseTranscription factors (TFs) control gene expression by binding DNA at genome’s regulatory regions with sequence-specific affinities. Accurate genome-wide measurements of binding affinities are cru
CURING LIVER DISEASES USING HUMAN CHEMICALLY INDUCED PLURIPOTENT STEM CELL-DERIVED FUNCTIONAL HEPATOCYTES
The liver, the largest internal organ in the human body, plays a central role in regulating virtually all metabolic processes. Liver dysfunction leads to a spectrum of diseases that severely disrupt human metabolism, which account for approximately 2 million deaths per year worldwide. Currently, liv
PERSONALIZED BRAIN FUNCTION SECTORS (PBFS) AND THEIR APPLICATION IN THE TREATMENT OF NEURODEGENERATIVE DISEASE
pBFS Foundation: DeepPrep – an accelerated, scalable, and robust deep learning–powered neuroimaging preprocessing pipelineNeuroimaging is entering the era of big data, driven by large-scale studies, data sharing initiatives, and international consortia.
HIGH-THROUGHPUT DEEP MUTATIONAL SCANNING (DMS) FOR PREDICTING SARS-COV-2 IMMUNE ESCAPE MUTATIONS
A world-leading platform for SARS-CoV-2 antibody/ vaccine studies was set up, allowing fast measurement of the immune pressure induced by infection and vaccination.
FROM CANCER METHYLOME ATLAS TO BLOOD-BASED SCREENING: A TARGETED MULTI-OMICS APPROACH FOR CFDNA MULTI-CANCER EARLY DETECTION
Utilizing blood cfDNA methylation for multi-cancer early detection (MCED) is ushering in a transformative era in cancer screening.
ONCOLYTIC VIRUS INDUCED PYROPTOSIS AS A NOVEL CANCER IMMUNOTHERAPY
We are developing a PD-1-ICB-based combo immunotherapy by targeting tumor cell pyroptosis.